https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52471 Wed 11 Oct 2023 20:44:03 AEDT ]]> ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46696 in vitro system that can be used to evaluate other IVDD therapies.]]> Tue 29 Nov 2022 09:49:28 AEDT ]]> Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54219 ACTA2), collagen (COL) 1A1 and fibulin-1 (Fbln1) and higher Fbln1 protein deposition after 7 days. Our results show that exposure of lung fibroblasts to fibrotic stiffness activates genes and secreted factors that are part of fibrotic responses and part of the Senescence-associated secretory phenotype (SASP). This overlap may contribute to the creation of a feedback loop whereby fibroblasts create a perpetuating cycle reinforcing progression of a fibrotic response.]]> Tue 13 Feb 2024 11:58:49 AEDT ]]> Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32076 Thu 27 Jan 2022 15:57:09 AEDT ]]> LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40825 Thu 18 Apr 2024 11:00:59 AEST ]]>